Evaluation of the power and type I error of recently proposed family-based tests of association for rare variants

BMC Proceedings

Table 1 Percent of significant genes at α = 0.05

	6454 Genes not containing a causal SNV		171 Genes containing at least 1 causal SNV
Method	Estimated kinship	Real kinship	Estimated kinship	Real kinship
$χ_{min}^{2}$	40.6% (2621/6454)	34.4% (2221/6454)	41.5% (71/171)	33.9% (58/171)
T²	5.2% (333/6454)	3.2% (209/6454)	1.8% (3/171)	1.2% (2/171)
CMC _5%	4.1% (267/6454)	3.3% (210/6454)	2.9% (5/171)	2.3% (4/171)
CMC _0.5%	5.3% (341/6454)	3.6% (235/6454)	2.9% (5/171)	2.3% (4/171)

ISSN: 1753-6561